Leader – Ph.D. in Biological Sciences, Senior Researcher, Korol Lesya.
The laboratory employs senior, senior and junior research staff, 2 laboratory assistants; of these – 2 candidates of medical sciences.
The laboratory is studying of biochemical mechanisms of the origin and progression of kidney diseases in children and adults; the study of the violations of blood lipid metabolism, peroxidation processes and antioxidant defense in the evolution of chronic kidney diseases.
The laboratory is working on the creation of informative methods for blood and urine research for the early diagnosis of kidney diseases and for forecasting their clinical course; participates in the evaluation of the effectiveness of various methods of treatment of nephrology patients, is engaged in the development of biochemical markers of kidney damage.
Practical orientation – the laboratory carries out the determination of enzyme specific for the kidneys (N-acetyl-β-D-glucosaminidase and its isoenzymes, β-galactosidase, L-arginine: glycine amidinotransferase, γ-glutamyltranspeptidase, glycosidase, arginase), iron transfer rates (transferrin, ceruloplasmin, index of saturation), inflammatory markers (C-reactive protein, urine peroxidase), antioxidant status evaluation of patients (catalase, peroxidase, ceruloplasmin, transferrin, SH-groups) and the intensity of oxidative stress in the patient.
The scientists of the laboratory developed methods for research on dyslipidemia as a risk factor for atherosclerosis in the progression of nephropathy and renal failure; definition of lysosomal and mitochondrial enzymes of the epithelium of proximal tubules, as sensitive indicators of early damage to the tubular apparatus of the kidneys in various kidney diseases; developed an integrated approach to the laboratory assessment of the state of antioxidant protection and the intensity of oxidative stress in the organism of patients.
The laboratory staff published more than 400 scientific papers in the field of biochemistry and nephrology, 30 patents were issued.